Can our kit be used for Cosmid purification?

Prepare a solution of 0.2N NaOH; 1% (w/v) SDS and substitute this for the current lysis buffer and follow the protocol as normal.

Because Cosmids are under 80kb (actually under 60kb) they don't require the modified BAC Lysis buffer in our kit. You could still use it; however, we've found standard lysis buffer improves the yield.

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